Human Fetal Hemoglobin F1

Synthesis of acetylated human fetal hemoglobin.

The in uitm biosynthesis of acetylated human fetal hemoglobin (Hb FI) was investigated in umbilical cord blood from two normal newborns and in peripheral blood from five adults with different hematologic disorders accompanied by elevated levels of fetal hemoglobin. Hemoglobin biosynthesis was measured by [8HJleucine incorporation into hemoglobin components which were separated by chromatograph...

Fetal hemoglobin production in cultures of primitive and mature human erythroid progenitors: differentiation affects the quantity of fetal hemoglobin produced per fetal-hemoglobin-containing cell.

Single-cell microscopic immunodiffusion assays were used to determine the cellular mechanisms that regulate fetal hemoglobin (HbF) levels in cultures of primitive and late erythroid precursors obtained from human adult bone marrow. Two variables--the percentage of cells containing HbF (F cells) and the picograms (pg) of HbF/F cell--were assayed in cells derived from erythroid colony-forming uni...

Induction of Fetal Hemoglobin

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A New Variant of Human Fetal Hemoglobin: Hb Froma.

The oxygen equilibrium of fetal and adult human hemoglobin.

Although the fetal and adult hemoglobins of many species, including man, are essentially similar in molecular weight and in spectroscopic characteristics, they exhibit marked differences in other chemical and physical properties (l-6). Therefore, they may be assumed to represent distinct chemical entities. The present study was undertaken to determine whether the chemical difference is expresse...